The toponym San Isidro, from the name of the saint Spanish Isidore the Farmer (in SpanishIsidro Labrador) can refer to several locations:
Argentina
- San Isidro, locality of the province of Buenos Aires
- San Isidro, locality of the province of Catamarca
- San Isidro, locality of the province of Formosa
- San Isidro, locality of the province of San Luis
- San Isidro, locality of the province of Santiago del Estero
- San Isidro, locality of the province of Salta
- San Isidro, locality of the province of Mendoza
- Partido of San Isidro, I leave of the province of Buenos Aires
Costa Rica
- canton of San Isidro, canton of the province of Heredia
- San Isidro, the capital district of the canton of the same name
- San Isidro, capital district of the canton of Vázquez de Coronado
- San Isidro, district of the canton of Alajuela
- San Isidro, district of the canton of Atenas
- San Isidro, district of the canton of El Guarco
- San Isidro, district of the canton of Greece
- San Isidro, district of the canton of León Cortés
- San Isidro, district of the canton of Montes de Oro
- San Isidro, district of the canton of San Ramón
- San Isidro de El General, capital district of the canton of Pérez Zeledón
El Salvador
- San Isidro, municipality of the Department of Cabañas
- San Isidro, municipality of the Department of Morazán
Philippines
- San Isidro, municipality in the province of Abra
- San Isidro, municipality in the Bohol province
- San Isidro, municipality in the province of Davao del Norte
- San Isidro, municipality in the Davao Oriental province
- San Isidro, municipality in the Isabela province
- San Isidro, municipality in the Leyte province
- San Isidro, municipality in the Northern Samar province
- San Isidro, municipality in the province of Nueva Ecija
- San Isidro, municipality in the province of Surigao del Norte
Honduras
- San Isidro, common in the Department of Choluteca
- San Isidro, municipality in the Department of Intibucá
Nicaragua
- San Isidro, common in the Department of Matagalpa
Peru
- San Isidro, district in the province of File
Dominican Republic
- San Isidro, air base a Santo Domingo
Spain
- San Isidro, municipality of the province of Alicante in Valencian community
- San Isidro de Abona (Granadilla de Abona-Santa Cruz de Tenerife)