Argentina
- San Cristóbal, barrio of Buenos Aires
- San Cristóbal, city of province of Santa Fe
- San Cristóbal, department of the province of Santa Fe
Bolivia
- San Cristóbal, Lipez mine
Chile
- Cerro San Cristóbal, hill of Santiago de Chile
Colombia
- San Cristóbal, municipality of the department of Bolívar
Costa Rica
- San Cristóbal, district of the canton of Desamparados
Cuba
- San Cristóbal, city and municipality of the province of Pinar del Río
- San Cristóbal de La Habana, another denomination of Havana
Ecuador
- San Cristóbal, island of Galápagos
Guatemala
- Ciudad San Cristóbal, city of the municipality of Mixco
- San Cristóbal Acasaguastlán, municipality
- San Cristóbal Cucho, municipality
- San Cristóbal Totonicapán, municipality
- San Cristóbal Verapaz, municipality
Solomon Islands
- San Cristóbal, ancient name of the province of Makira
Mexico
- San Cristóbal de las Casas, city in the state of Chiapas
- San Cristóbal Ecatepec, barrio of Hecatepec
Nicaragua
- San Cristóbal, volcano
Paraguay
- San Cristóbal, district of the department of]] Alto Paraná]]
Peru
- San Cristóbal, district of the province of Luya, in the Region of Amazonas
- San Cristóbal, district of the province of Picota, in San Martín region
- San Cristóbal, district of the province of Lucanas, in Ayacucho region
- San Cristóbal, district of the province of Ocros, in the Region of Ancash
Dominican Republic
- San Cristóbal, capital city of the province of San Cristóbal
Spain
- San Cristóbal de La Laguna, common
United States of America
- San Cristobal, village of Taos County, in New Mexico
Venezuela
- San Cristóbal, city