The term San Sebastián, often too San Sebastian, is a toponym Spanish which literally means San Sebastian and can have different meanings:
Colombia
- San Sebastián, common in Department of Cauca
- San Sebastián de Buenavista, common in Magdalena Department
- San Sebastián de Mariquita common in Tolima Department
Costa Rica
- San Sebastián, district in the canton of San José
El Salvador
Philippines
- San Sebastian (Samar), municipality in Samar Province
Guatemala
- San Sebastián, common in the Department of Retalhuleu
- San Sebastián Coatán, common in the Department of Huehuetenango
- San Sebastián Huehuetenango, common in the Department of Huehuetenango
Honduras
- San Sebastián, municipality in the Comayagua Department
- San Sebastián, common in the Department of Lempira
Mexico
- San Sebastián del Oeste, city
Nicaragua
- San Sebastián de Yalí, common in the Jinotega Department
Puerto Rico
Spain
- San Sebastián, city of the Basque country
- San Sebastián de la Gomera, city of Canary Islands