The term Santa Isabel is a toponym Spanish is Portuguese which literally means "Santa Isabella" and can indicate
Argentina
- Santa Isabel, city in the province of The Pampas
- Santa Isabel, locality in the province of Santa Fe
Brazil
- Santa Isabel (Goiás), common
- Santa Isabel (San Paolo), common
- Santa Isabel do Ivaí, common
- Santa Isabel do Pará, common
- Santa Isabel do Rio Negro, common
Ecuador
- Santa Isabel, capital of the canton of Santa Isabel in the province of Azuay
Colombia
- Santa Isabel (Colombia), municipality of the department of Tolima
Equatorial Guinea
- Santa Isabel, original name of Malabo
Mexico
- Santa Isabel (Mexico), municipality of the State of Chihuahua, Mexico
Portugal
- Santa Isabel, fraction of Lisbon
Puerto Rico
Solomon Islands
- Santa Isabel (Solomon Islands), island of Solomon Islands