Liberia
- Greenville, county seat of Greenville District and Sinoe County
United States of America
- Greenville, the county seat of Butler County, Alabama
- Greenville, census-designated place in Plumas County, California
- Greenville, the county seat of Pitt County, North Carolina
- Greenville, the county seat of Greenville County, South Carolina
- Greenville, census-designated place in New Castle County, Delaware
- Greenville, city in Madison County, Florida
- Greenville, the county seat of Meriwether County, Georgia
- Greenville, the county seat of Bond County, Illinois
- Greenville, a city in Floyd County, Indiana
- Greenville, a town in Clay County, Iowa
- Greenville, the county seat of Muhlenberg County, Kentucky
- Greenville, city of Piscataquis County, Maine
- Greenville, a city in the County of Montcalm, Michigan
- Greenville, a city in Washington County, Mississippi
- Greenville, Wayne County Town, Missouri
- Greenville, a town in Hillsborough County, New Hampshire
- Greenville, a city in Greene County, New York
- Greenville, a city in Orange County, New York
- Greenville, a city in Darke County, Ohio
- Greenville, Somerset County township, Pennsylvania
- Greenville, borough of Mercer County, Pennsylvania
- Greenville, town in Hunt County, Texas
- Greenville, census-designated place in Augusta County, Virginia
- Greenville, city of Outagamie County, Wisconsin