Argentina
- Santa Rosa, capital of the Province of La Pampa
- Santa Rosa, capital of the Department of Santa Rosa, Mendoza province
- Santa Rosa de Calamuchita, city of Province of Córdoba
- Santa Rosa de Conlara, capital of the Junín Department, Province of San Luis
- Santa Rosa de Río Primero, city of the Province of Córdoba
Bolivia
- Santa Rosa, municipality of Department of Goods
Brazil
- Santa Rosa, city of Rio Grande do Sul
- Santa Rosa de Viterbo, municipality of the state of St. Paul
Colombia
- Santa Rosa, municipality of Bolívar Department
- Santa Rosa, municipality of Department of Cauca
- Santa Rosa de Cabal, municipality of Risaralda Department
- Santa Rosa de Osos, municipality of Department of Antioquia
- Santa Rosa de Viterbo, municipality of Boyacá Department
- Santa Rosa del Sur, municipality of the Department of Bolívar
Costa Rica
- Santa Rosa, district of the canton of Oreamuno
- Santa Rosa, district of the canton of Santo Domingo
- Santa Rosa, district of the canton of Tilarán
- Santa Rosa, district of the canton of Turrialba
Ecuador
- Santa Rosa, chief town of the canton of Santa Rosa in the Province of El Oro
El Salvador
- Santa Rosa de Lima, municipality of the Department of La Unión
Philippines
- Santa Rosa, city of province of Laguna
- Santa Rosa, municipality of the Province of Nueva Ecija
Guatemala
- Santa Rosa de Lima, municipality of the Department of Santa Rosa
- Nueva Santa Rosa, municipality of the Department of Santa Rosa
Honduras
- Santa Rosa de Aguán, municipality of the Department of Colón
- Santa Rosa de Copán, capital of the Copán Department
Nicaragua
- Santa Rosa del Peñón, municipality of the Department of León
Paraguay
- Santa Rosa, district of the Department of Misiones
- Santa Rosa del Mbutuy, district of the Department of Caaguazú
- Santa Rosa on Monday, district of the Department of Alto Paraná
United States of America
- Santa Rosa, census-designated place in Pima County, Arizona
- Santa Rosa, the county seat of Sonoma County, California
- Santa Rosa, capital of Guadalupe County, New Mexico
- Santa Rosa, a city in Cameron County, Texas
- Santa Rosa Island, island of the archipelago of Channel Islands, California
Uruguay
- Santa Rosa, city of the Department of Canelones