Argentina
- Santa Clara, a town in the department of Coronel Felipe Varela in the province of La Rioja
- Santa Clara, a town in the department of Santa Bárbara in the province of Jujuy
Brazil
- Santa Clara do Sul, a town in the state of Rio Grande do Sul
Chile
- Santa Clara, island of the archipelago Juan Fernández off the coast of Chile
- Santa Clara, a town on the Mallarauco River, southwest of Santiago de Chile
Colombia
- Santa Clara, a town on the Yaguas River in the Amazonas department, bordering the Brazil
Cuba
- Santa Clara, in the province of Villa Clara
Ecuador
- Santa Clara Island, in the Gulf of Guyaquil
- Santa Clara, capital of the Canton of Santa Clara
El Salvador
Gabon
Guatemala
- Santa Clara la Laguna, municipality of the department of Sololá
Mexico
- Santa Clara in Durango
- Santa Clara del Cobre, in Michoacán
- Santa Clara, on the homonymous river, in the state of Chihuahua
- Santa Clara River, which flows in the state of Chihuahua
Portugal
- in Coimbra, Portuguese freguesia
- in Ponta Delgada, Portuguese freguesia
United States of America
- Santa Clara, capital of the county of Santa Clara, California
- Santa Clara, a city in Franklin County, New York
- Santa Clara, Grant County Village, New Mexico
- Santa Clara, city of Guadalupe County, Texas
- Santa Clara, city in Washington County, Utah