Santa Fe ("Santa Fede" in Spanish) or Santa Fé (in Portuguese with the same meaning) can refer to:
Argentina
- Santa Fe, capital of the homonymous province
- Santa Fe province
Brazil
- Santa Fé, municipality of the state of Paraná
- Santa Fé de Goiás, municipality of the state of Goiás
- Santa Fé de Minas, municipality of the state of Minas Gerais
- Santa Fé do Sul, municipality of the state of St. Paul
Colombia
- Santa Fe de Antioquia, municipality of Department of Antioquia
- Santa Fe de Bogotá, or also Santafé de Bogotá, old name of the capital
Philippines
- Santa Fe, municipality of the Cebu Province
- Santa Fe, municipality of the Leyte province
- Santa Fe, municipality of the province of Nueva Vizcaya
- Santa Fe, municipality of the Romblon province
Honduras
- Santa Fe, municipality of the department of Colon
- Santa Fe, municipality of the department of Ocotepeque
Mexico
- Santa Fe, Mexico City
- Santa Fe, municipality of the state of Baja California Sur
- Santa Fe, municipality of the state of Chihuahua
- Santa Fe, municipality of the state of Coahuila
- Santa Fe, municipality of the state of Guanajuato
- Santa Fe, municipality of the state of Jalisco
- Santa Fe, municipality of the state of Michoacán
- Santa Fe, municipality of the state of Nayarit
- Santa Fe, municipality of the state of Nuevo León
- Santa Fe, municipality of the state of Sinaloa
- Santa Fe, municipality of the state of Veracruz
Panama
Spain
- Santa Fe, municipality of province of Granada
United States of America
- Santa Fe, capital of New Mexico
- Santa Fe, in Florida
- Santa Fe, in Missouri
- Santa Fe, in Tennessee
- Santa Fe, in Texas
- Rancho Santa Fe, in California