Santa Cruz ("Santa Croce" in Spanish is Portuguese), is the name of several cities, regions and other places in the world:
Argentina
- Santa Cruz, a town in the department of Famatina in the province of La Rioja
- Santa Cruz, river
- province of Santa Cruz
Bolivia
- Santa Cruz de la Sierra
- department of Santa Cruz
Brazil
- Santa Cruz, common in the state of Paraíba
- Santa Cruz, common in the state of Pernambuco
- Santa Cruz, common in the state of Rio Grande do Norte
- Santa Cruz do Arari, common in the state of Para
- Santa Cruz da Baixa Verde, common in the state of Pernambuco
- Santa Cruz Cabrália, common in the state of Bahia
- Santa Cruz do Capibaribe, common in the state of Pernambuco
- Santa Cruz da Conceição, common in the state of St. Paul
- Santa Cruz do Escalvado, common in the state of Minas Gerais
- Santa Cruz da Esperança, common in the state of São Paulo
- Santa Cruz de Goiás, common in the state of Goiás
- Santa Cruz dos Milagres, common in the state of Piaui
- Santa Cruz de Minas, common in the state of Minas Gerais
- Santa Cruz de Monte Castelo, common in the state of Paraná
- Santa Cruz das Palmeiras, common in the state of São Paulo
- Santa Cruz do Piauí, municipality in the state of Piauí
- Santa Cruz do Rio Pardo, common in the state of São Paulo
- Santa Cruz de Salinas, common in the state of Minas Gerais
- Santa Cruz do Sul, common in the state of Rio Grande do Sul
- Santa Cruz da Vitória, common in the state of Bahia
- Santa Cruz, district of the city of Rio de Janeiro
Cape Verde
- county of Santa Cruz
Chile
- Santa Cruz, municipality of the province of Colchagua
Colombia
- Santa Cruz, municipality of the department of Nariño
- Santa Cruz de Lorica, municipality of the department of Córdoba
Costa Rica
- Canton of Santa Cruz, canton of Guanacaste province
- Santa Cruz, district of the canton of Leon Cortés
- Santa Cruz, the capital district of the canton of the same name
- Santa Cruz, district of the canton of Turrialba
Cuba
Dominican Republic
Ecuador
Philippines
- Santa Cruz, municipality in the province of Davao del Sur
- Santa Cruz, municipality in the province of Ilocos Sur
- Santa Cruz, municipality in the province of Lagoon
- Santa Cruz, municipality in the province of Marinduque
- Santa Cruz, municipality in the province of Occidental Mindoro
- Santa Cruz, municipality in the province of Zambales
Guatemala
- Santa Cruz Balanyá, municipality of the department of Chimaltenango
- Santa Cruz Barillas, municipality of the department of Huehuetenango
- Santa Cruz del Quiché, capital of the department of Quiche
- Santa Cruz el Chol, municipality of the department of Baja Verapaz
- Santa Cruz la Laguna, municipality of the department of Sololá
- Santa Cruz Muluá, municipality of the department of Retalhuleu
- Santa Cruz Naranjo, municipality of the department of Santa Rosa
- Santa Cruz Verapaz, municipality of the department of Alta Verapaz
Honduras
- Santa Cruz, municipality of the department of Lempira
- Santa Cruz de Yojoa, municipality of the department of Cortés
India
- Santacruz, a suburb of Mumbai
- Santa Cruz, a city in the state of Goa
Mexico
- Santa Cruz de Juventino Rosas
- Santa Cruz, municipality in the state of Sonora
Peru
- Santa Cruz de Flores, department of the region of File
- province of Santa Cruz, province of the region of Cajamarca
- Santa Cruz, capital of the Cajamarca Region
Portugal
- Santa Cruz, municipality of the autonomous region of Madeira
- Santa Cruz da Graciosa, municipality of the autonomous region of Azores
- Santa Cruz, freguesia of the municipality of Almodôvar
- Santa Cruz, freguesia of the municipality of Armamar
- Santa Cruz, freguesia of the municipality of Coimbra
- Santa Cruz, freguesia of the municipality of Santa Cruz, Madeira
- Santa Cruz, freguesia of the municipality of Lagoa, Azores
- Santa Cruz, freguesia of the municipality of Praia da Vitória, Azores
- Santa Cruz, freguesia of the municipality of Santiago do Cacém
- Santa Cruz, freguesia of the municipality of Vinhais
- Santa Cruz da Graciosa, freguesia of the municipality of Santa Cruz da Graciosa
- Santa Cruz das Flores, freguesia of the island and municipality of Flores, Azores
- Santa Cruz da Trapa, freguesia of the municipality of São Pedro do Sul
- Santa Cruz do Bispo, freguesia of the municipality of Matosinhos
- Santa Cruz do Douro, freguesia of the municipality of Baião
- Santa Cruz do Lima, freguesia of the municipality of Ponte de Lima
- Santa Cruz - Trindade, freguesia of the municipality of Chaves
Solomon Islands
Spain
- Santa Cruz del Valle de los Caídos, Madrid
- Santa Cruz de Boedo, Palencia
- Santa Cruz de Bezana, Cantabria
- Santa Cruz de Grío, Zaragoza
- Santa Cruz de la Salceda, Burgos
- Santa Cruz de la Serós, Huesca
- Santa Cruz de Tenerife, a city of Canary Islands
- province of Santa Cruz de Tenerife, a province of the Canary Islands
- Santa Cruz de la Palma, capital ofisland of La Palma, Canary
United States of America
- Santa Cruz, the county seat of Santa Cruz, California
- Santa Cruz, census-designated place in Santa Fe County, New Mexico
- Santa Cruz, census-designated place in County Starr, Texas
- Santa Cruz, river ofArizona
- county of Santa Cruz, California county
- county of Santa Cruz, county of Arizona